Clock excitability, circadian rhythms and healthy ageing
The CircadiAgeing project explores how disruptions in circadian rhythms, the natural 24-hour cycles of physiological and behavioural patterns, contribute to ageing and related health issues.
Circadian rhythms become weaker as we age leading to poorer sleep and contributing to diseases such as Alzheimer’s disease. This BBSRC strategic larger and longer grant marks a major investment of UKRI supporting researchers at Bristol, Exeter, Imperial, Kings and Manchester to investigate exactly how ageing affects circadian rhythms.
Using interdisciplinary methods including cutting-edge genetic analysis and computational biology, the research team hopes to develop interventions that could restore the robustness of these biological clocks, promoting healthier ageing and potentially reducing age-related disorders.
News and events
sLola Circadageing grant launch
The sLola Circadageing grant launch will take place from Monday 1st-Tuesday 2nd September 2025.
Circadiageing represented at recent workshops
Circadiageing principal investigator Dr Alessio Vagnoni recently spoke at two workshops.
Dementia and Brain Health event
Alzheimer’s Research UK Southwest and University of Bristol Dementia Research theme are hosting an event.